Nepal’s political landscape has witnessed significant changes in recent years, with frequent shifts in leadership and evolving dynamics in its foreign policy. The “change of guard” in Nepal, marked by the rise of new political leaders and parties, has had a profound impact on Indo-Nepal relations. Historically, India and Nepal have shared a unique relationship characterized by open borders, cultural ties, and deep-rooted people-to-people connections. However, Nepal’s internal political instability and its efforts to balance relations with India and China have introduced complexities into this relationship. The rise of the Communist Party of Nepal (CPN) and its unification with other leftist factions brought a shift in Nepal’s foreign policy, with a greater emphasis on reducing dependency on India and strengthening ties with China. Projects like the Belt and Road Initiative (BRI) and increased Chinese investments in infrastructure have raised concerns in India about Nepal’s strategic alignment. However, the recent dissolution of the CPN and the emergence of new political forces have opened opportunities for India to re-engage with Nepal. India remains a key partner for Nepal, providing economic aid, infrastructure development, and disaster relief. However, issues like border disputes, trade imbalances, and Nepal’s new constitution have occasionally strained ties. The change of guard in Nepal offers a chance to reset bilateral relations, focusing on mutual trust, economic cooperation, and addressing shared challenges. For India, maintaining a stable and friendly Nepal is crucial for regional security and countering China’s growing influence in South Asia. “Change of Guard in Nepal and Indo-Nepal Relations” examines the impact of Nepal’s political transitions on its bilateral ties with India, exploring the challenges and opportunities in this evolving relationship.